Latin America is historically one of the most unequal regions in the world. In addition to their historical persistence, social inequalities in Latin America are characterized by being heavily influenced by global processes. Interdependencies with world markets, international legal structures and practices as well as sectoral policies (related to economy, trade, migration, human rights, science, etc.) strongly influence the creation, structuring and transformation of social inequalities in Latin America. Despite the increasingly transnational and global character of processes affecting inequality, social actors must still address national and subnational political spaces when they seek to mediate the social, political and ecological impact of globally structured inequalities. The 3rd International Conference of desiguALdades.net thus focuses on these discrepancies between the global configuration of inequalities and the persistence of national and subnational arenas in which these inequalities are negotiated.